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Safety in TRIUMPH-1 The safety profile was consistent with incretin-class therapies: Most common AEs (12 mg dose): - Nausea: 42.4% - Diarrhea: 32.0% - Constipation: 26.1% - Vomiting: 25.3% Dysesthesia (a sensory disturbance tingling, numbness) and urinary tract infections were reported in approximately 10% of patients on the highest doses, but were generally mild to moderate and mostly resolved during treatment
The most common side effects are gastrointestinal nausea, constipation, diarrhea, and bloating particularly during the first 4 to 8 weeks when doses are being increased
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3bd) clearly induced phosphorylation of Met alone (Fig
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